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Investigation of antimicrobial use and the impact of antimicrobial use guidelines in a small animal veterinary teaching hospital: 1995-2004.

Weese JS

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

OBJECTIVE: To evaluate patterns of antimicrobial use and the impact of antimicrobial use guidelines at a small animal veterinary teaching hospital. DESIGN: Retrospective study. SAMPLE POPULATION: All antimicrobial prescriptions for dogs and cats admitted to the hospital in 1995 through 2004. PROCEDURE: Pharmacy records were reviewed, and antimicrobial prescriptions for all dogs and cats admitted during the study period were recorded. Amounts of individual drugs dispensed directly to the intensive care and surgical units were determined. Changes in antimicrobial use during the study period were assessed; changes in antimicrobial use patterns in 2000 through 2004 were evaluated to assess the impact of implementation of antimicrobial use guidelines in 2001. RESULTS: There was a significant decrease in prescriptions/1,000 admissions during the study period. From 1995 to 2004, the use of first-generation cephalosporins, fluoroquinolones, penicillins, and trimethoprim-sulfonamides decreased, whereas the use of metronidazole increased. The use of first-generation cephalosporins, fluoroquinolones, and penicillins decreased from 2000 to 2004. First-line drugs accounted for 90.7% of prescriptions during the study period. The use of third-line drugs decreased from 2000 to 2004. CONCLUSIONS AND CLINICAL RELEVANCE: Characterization of antimicrobial use is an important step in defining and evaluating the prudent use of antimicrobials. Whereas the true effect of antimicrobial use guidelines is unclear, these results suggest that the guidelines may have had an effect on antimicrobial prescription patterns in this small animal veterinary teaching hospital. Analysis of objective data regarding antimicrobial use and changes in antimicrobial use patterns over time is important in veterinary practices.

Published 15 February 2006 in J Am Vet Med Assoc, 228(4): 553-8.
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